In 1685, the Sun King Louis XIV revokes the Edict of Nantes and initiates a policy of religious persecution of French Protestants. In England, the Catholic James II assumes the throne to the horror of the Protestant majority in Parliament. From their exiles in the Dutch Republic, the French philosopher Pierre Bayle writes his groundbreaking defense of religious tolerance “Commentaire Philosophique”, and John Locke the original Latin version of his Letter Concerning Toleration. In this episode, we trace the seeds of the Enlightenment covering events in France, the Dutch Republic, and England.